• Rahayu Utami Utami Sekolah Tinggi Ilmu Farmasi Riau
  • Ginta Rio Maranti
  • Mustika Furi
  • Melzi Octaviani
  • Septi Muharni
  • Fina Aryani
  • Husnawati
  • Wira Noviana Suhery
  • Musyirna Rahmah Nst
  • Haiyul Fadhli STIFAR Riau
  • Emma Susanti
  • Emrizal




AlCl3 , antioksidan, Dillenia suffroticosa, Folin Ciocalteu, Riau


Simpur air is one of plant that has been using as traditional medicine for treating several diseases. Some studies on its chemical constituents and biological activities of this species have been published. However, chemical constituents and antioxidant activity of this plant which is Riau origin has not been reported before. This study aims to determine the total of phenolic and flavonoid content as well as its antioxidant activity of methanol extracts of roots, leaves and flowers of simpur air. Determination of total of phenolic and flavonoid content was performed by spectrophotometric method using Folin Ciocalteu and AlCl3 as reagents, respectively. Whereas, its antioxidant activity was evaluated using DPPH method. The results showed that methanol extracts of its roots afforded the highest total of phenolic and flavonoid content and also its antioxidant activity. The total of phenolic content of methanol extracts of its roots of 428.131 GAE/mg extract; its total of flavonoid content of 766.164 QE/mg extract; as for its antioxidant activity gave IC50 value of 3.852 µg/ml.


Download data is not yet available.


Alam, M.N., Bristi, N.J. & Rafiquzzaman, M. 2013. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharmaceutical Journal, .

Armania, N., Yazan, L.S., Ismail, I.S., Foo, J.B., Tor, Y.S., Ishak, N., Ismail, N. & Ismail, M. 2013a. Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via Induction of G2/M arrest and apoptosis. Molecules, 18(11).

Armania, N., Yazan, L.S., Musa, S.N., Ismail, I.S., Foo, J.B., Chan, K.W., Noreen, H., Hisyam, A.H., Zulfahmi, S. & Ismail, M. 2013b. Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest. Journal of Ethnopharmacology, 146(2).

Foo, J.B., Saiful Yazan, L., Tor, Y.S., Wibowo, A., Ismail, N., Armania, N., Cheah, Y.K. & Abdullah, R. 2016. Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells. Journal of Ethnopharmacology, 187.

Foo, J.B., Yazan, L.S., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. & Ismail, M. 2014. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. BMC Complementary and Alternative Medicine, 14.

Liu, H., Song, Y. & Zhang, X. 2017. Determination of total flavonoids in leek by AlCl3 colorimetric assay. Chemical Engineering Transactions, 59.

Matić, P., Sabljić, M. & Jakobek, L. 2017. Validation of Spectrophotometric Methods for the Determination of Total Polyphenol and Total Flavonoid Content. Journal of AOAC International, 100(6).

Muharini, R., Lestari, I. & Masriani, M. 2021. Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark. Pharmaciana, 11(2).

Muliawan, S.Y. 2008. Effect of Dillenia suffruticosa extract on dengue virus type 2 replication. Universa Medicina, 27(1).

Sabandar, C.W., Jalil, J., Ahmat, N. & Aladdin, N.A. 2017. Medicinal uses, chemistry and pharmacology of Dillenia species (Dilleniaceae). Phytochemistry, .

Sarker, S.D., Latif, Z. & Gray, A.I. 2006. Natural Product Isolation. Natural Products Isolation.

Shahidi, F. & Ambigaipalan, P. 2015. Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects - A review. Journal of Functional Foods, .

Terahara, N. 2015. Flavonoids in foods: A review. Natural Product Communications, .

Tor, Y.S., Yazan, L.S., Foo, J.B., Armania, N., Cheah, Y.K., Abdullah, R., Imam, M.U., Ismail, N. & Ismail, M. 2014. Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complementary and Alternative Medicine, 14.

Wiart, C., Mogana, S., Khalifah, S., Mahan, M., Ismail, S., Buckle, M., Narayana, A.K. & Sulaiman, M. 2004. Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia. Fitoterapia, 75(1).

Xu, B.J. & Chang, S.K.C. 2007. A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. Journal of Food Science, 72(2).




How to Cite

Utami, R. U., Ginta Rio Maranti, Mustika Furi, Melzi Octaviani, Septi Muharni, Fina Aryani, Husnawati, Wira Noviana Suhery, Musyirna Rahmah Nst, Fadhli, H., Emma Susanti, & Emrizal. (2021). KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook). Jurnal Penelitian Farmasi Indonesia, 10(2), 1–6. https://doi.org/10.51887/jpfi.v10i2.1418




Most read articles by the same author(s)