PENGARUH TEKNIK LIQUISOLID MENGGUNAKAN TRANSCUTOL® HP TERHADAP DISOLUSI ASAM FENOFIBRAT
DOI:
https://doi.org/10.51887/jpfi.v12i2.1905Abstract
Kelarutan merupakan salah satu parameter yang dapat mempengaruhi ketersediaan hayati obat. Obat-obatan dengan kelarutan yang rendah membutuhkan dosis tinggi untuk mencapai konsentrasi oral terapeutik. Asam fenofibrat adalah obat yang memiliki kelarutan dalam air yang rendah dan permeabilitas yang tinggi. Salah satu cara untuk mengatasi masalah kelarutan adalah dengan teknik liquisolid. Penelitian ini bertujuan untuk mengetahui pengaruh teknik liquisolid asam fenofibrat terhadap disolusinya. Formulasi dengan teknik liquisolid dibuat dengan jenis dan jumlah yang bervariasi menggunakan pelarut Transcutol® HP, bahan pembawa Neusilin® US2 serta bahan penyalut Aerosil® 200. Formulasi liquisolid dibuat dengan perbandingan 1:4 (F1); 1:8 (F2); dan 1:12 (F3). Formulasi terbaik kemudian dilihat dari faktor Hausner, kompresibilitas, porositas, kecepatan alir, sudut istirahat dan uji disolusi. Hasil evaluasi menunjukkan adanya perubahan bentuk mikroskopis liquisolid asam fenofibrat dan perbedaan terhadap hasil evaluasi dan disolusi antar formula. Berdasarkan hasil uji statistik ANOVA menunjukkan asam fenofibrat yang dibuat dengan teknik liquisolid dapat meningkatkan laju disolusi dibandingkan dengan asam fenofibrat murni. Berdasarkan hasil semua evaluasi, formulasi terbaik dengan peningkatan disolusi paling tinggi adalah F3, dengan nilai ED60 = 83,2%.
Solubility is one of the parameters that can influence the bioavailability of drugs. Drugs with low solubility require high doses to achieve therapeutic oral concentrations. Fenofibric acid is a drug that has low solubility and high permeability. One way to overcome the solubility problem is with the liquisolid technique. This research aims to determine the effect of the fenofibric acid liquisolid technique on its dissolution. Formulations using the liquisolid technique are made in varying types and quantities using Transcutol® HP as solvent, Neusilin® US2 as carrier material and Aerosil® 200 as coating material. Liquid formulations are made in a ratio of 1:4 (F1); 1:8 (F2); and 1:12 (F3). The best formulation is based on the Hausner factor, compressibility, porosity, flow properties, angle of repose and dissolution test. The evaluation results showed changes in the microscopic shape of the liquisolid fenofibric acid and differences in evaluation and dissolution results between formulas. Based on the results of the ANOVA statistical test, it show that fenofibric acid made using the liquisolid technique can increase the dissolution rate compared to pure fenofibric acid. Based on the results of all evaluations, the best formulation with the highest dissolution increase is F3, with an ED60 value = 83.2%.
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