OPTIMASI FORMULA STICK BALM MINYAK ATSIRI DAUN SEREH (Cymbopogon citratus)

Authors

  • I Komang Ary Werdhi Widnyana Universitas Mataram
  • Windah Anugrah Subaidah Universitas Mataram
  • Nisa Isneni Hanifa

DOI:

https://doi.org/10.51887/jpfi.v10i2.1417

Keywords:

optimal, lemongrass, stick balm, simplex lattice design

Abstract

The content in lemongrass leaves essential oil (Cymbopogon citratus) has a neurobehavioral effect, so lemongrass leaves essential oil can be useful as aromatherapy. The stick balm form as an innovation of aromatherapy form is required to increase the user’s comfort and ease of application of the product. The aim of this study is to determine the optimum formula and physical properties of lemongrass essential oil stick balm form with additive variations of cera alba and lanolin. Eight stick balm formula designs were determined by using SLD (Simplex Lattice Design), method with Design Expert 11 software, and made by using melting method. The stick balm forms were tested for the physical properties such as pH test, melting point test, and adhesion test. The response to the physical properties test was processed by using Design Expert 11 software to obtain optimal formula. The optimal form of stick balm was tested for physical, organoleptic, and homogeneity properties. The results of the physical properties test of optimal formula were verified by using one sample t-test method with SPSS software. The results of the optimization of the formula were 5,310% of lanolin and 11,690% of cera alba. The stick balm forms were bright yellow in color, have a characteristic smell of lemongrass essential oil, semi-solid consistency, homogeneous mixed materials, pH level of 5,63±0,06, melting point of 44,5±0,5oC, and adhesion tests of 2,437±0,106 seconds, with the result that, the optimum formula of stick balm met requirements for the physical properties. The physical properties of the optimal formula are not significantly different from the predictions in the Design Expert 11 application.

References

Anief, M. 2013. Ilmu Meracik Obat : Teori dan Praktik Edisi ke-16. Yogyakarta: Gadjah Mada University Press.

Anjari, W., Taurina, W., & Purwanti, N. U. 2015. Pengaruh Cera Alba Terhadap Sifat Fisik Lip Gloss Ekstrak Etanol Biji Kesumba Keling (Bixa orellana L.). Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 3(1): 1 - 13.

Arisanti, C. I. S., Indraswari, P. I. I., & Budiputra, D. K. 2016. Pengaruh komposisi span ® 80 dan cera alba terhadap stabilitas fisik sediaan cold cream ekstrak etanol 96 % kulit buah manggis (Garcinia mangostana L). Skripsi, Universitas Udayana, Bali.

Astuti, I. Y., Hartanti, D., & Aminiati, A. 2010. Peningkatan Aktivitas Antijamur Candida albicans Salep Minyak Atsiri Daun Sirih (Piper bettle Linn.) melalui Pembentukan Kompleks Inklusi dengan B-Siklodekstrin. Traditional Medicine Journal, 15(3): 94–99.

Athaillah, & Lianda, S. O. 2021. Formulasi dan Evaluasi Sediaan Balsem Stik dari Oleoresin Jahe Merah (Zingiber officinale rosc) Sebagai Pereda Nyeri Otot dan Sendi. Journal of Pharmaceutical And Sciences, 4(1): 34–40. https://doi.org/10.36490/journal-jps.com.v4i1.62

Azkiya, Z., Ariyani, H., & Nugraha, T. 2017. Evaluasi Sifat Fisik Krim Ekstrak Jahe Merah (Zingiber officinale Rosc. var. rubrum) sebagai Antinyeri. Journal of Current Pharmaceutica Sciences, 1(1): 12–18.

Blanco, M. M., Costa, C. A. R. A., Freire, A. O., Santos, J. G., & Costa, M. (2009). Neurobehavioral Effect of Essential Oil of Cymbopogon citratus in mice. Phytomedicine, 16(2–3): 265–270. https://doi.org/10.1016/j.phymed.2007.04.007

Butler, H. 2000. Pouchers Perfumes, Cosmetics, and Soaps (10th ed.). New York: Kluwer Academic Publisher.

Fitriana, A. Y., Wahyuningrum, R., & Sudarso. 2012. Daya Repelan dan Uji Iritasi Formula Lotion Ekstrak Etanol Daun Sirih (Piper bettle Linn.) dengan Variasi Basis Lanolin Terhadap Nyamuk Aedes aegypti. Pharmacy, 9(2): 1–9.

Gaware, V. M., Nagare, R., Dhamak, K. B., Khadse, A. N., Kotade, K. B., Kashid, V. A., & Laware, R. B. 2013. Aromatherapy: Art or Science. International Journal of Biomedical Research, 4(2): 10. https://doi.org/10.7439/ijbr

Gumbara, Y. T., Murrukmihadi, M., & Mulyani, S. 2015. Optimasi Formula Sediaan Lipstik Ekstrak Etanolik Umbi Ubi Jalar Ungu (Ipomoea batatas L.) dengan Kombinasi Basis Carnauba Wax dan Paraffin Wax Menggunakan Metode SLD (Simplex Lattice Design). Majalah Farmaseutik, 11(3): 336–345.

Irianto, I. D. K., Purwanto, P., & Mardan, M. T. 2020. Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper bettle L.) Sebagai Alternatif Pengobatan Mastitis Sapi. Majalah Farmaseutik, 16(2): 202 - 210. https://doi.org/10.22146/farmaseutik.v16i2.53793

Ittiqo, D. H., & Wahid, A. R. 2019. Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi pada Kelinci. Pharmauho: Jurnal Farmasi, Sains, Dan Kesehatan, 4(2): 14 - 21. https://doi.org/10.33772/pharmauho.v4i2.6258

Kementerian Kesehatan RI. 2018. Hasil Utama Riset Kesehatan Dasar 2018. Jakarta: Kementrian Kesehatan RI.

Maysarah, H., Sari, I., Faradilla, M., & Elfia Rosa, E. 2020. Stick Perfume Formulation from Jeumpa Flowers (Magnolia champaca (L) Baill Ex. Pierre). Proceedings of the 2nd International Conference of Essential Oils (ICEO 2019), L, 47–53. https://doi.org/10.5220/0009956100470053

Naibaho, O. H., Yamlean, P. V. Y., & Wiyono, W. 2013. Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus. Jurnal Ilmiah Farmasi-UNSRAT, 2(02): 27–34.

Novita, R., Munira, M., & Hayati, R. 2017. Formulasi Sediaan Salep Ekstrak Etanol Pliek U Sebagai Antibakteri. AcTion: Aceh Nutrition Journal, 2(2): 103–108. https://doi.org/10.30867/action.v2i2.62

Paramita, A. 2008. Optimasi formula span 80 dan tween 80 dalam cold cream obat luka ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis.) dengan metode simplex lattice design. Skripsi, Universitas Sanata Dharma, Yogyakarta.

Purba, O. H., Tumanggor, N. T., Syafitri, A., & Simorangkir, D. M. 2020. Pembuatan Sediaan Balsem Stick dari Sereh (Cymbopogon citratus (DC.) Stapf). Jurnal Penelitian Farmasi & Herbal, 3(1): 75–81.

Rachmawati, D., Stevani, H., & Santi, E. 2018. Uji Stabilitas Mutu Fisik Sediaan Masker Gel Wajah dari Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) dengan Variasi Konsentrasi Carbopol. Media Farmasi, 14(1): 85–92. https://doi.org/10.32382/mf.v14i1.75

Rohmani, S., & Kuncoro, M. A. A. 2019. Uji Stabilitas dan Aktivitas Gel Handsanitizer Ekstrak Daun Kemangi. JPSCR : Journal of Pharmaceutical Science and Clinical Research, 4(1): 16–28. https://doi.org/10.20961/jpscr.v4i1.27212

Rowe, R. C., Sheskey, P. J., & Owen, S. C. 2006. Handbook of Pharmaceutical Excipients Fifth Edition. New York: Royal Pharmaceutical Society of Great Britain.

Sandi, D. A. D., & Musfirah, Y. 2018. Pengaruh Basis Salep Hidrokarbon dan Basis Salep Serap terhadap Formulasi Salep Sarang Burung Walet Putih. Jurnal Ilmiah Manuntung, 4(2): 149–155.

Sisco Research Laboratories Ltd., P. (2021a). Bees Wax pure. https://srlchem.com/products/product_details/productId/143014/Bees-Wax-pure-8012-89-3, diakses 19 Oktober 2021.

Sisco Research Laboratories Ltd., P. (2021b). Lanolin Anhydrous Extrapure. https://www.srlchem.com/products/product_details/productId/142516/Lanolin-anhydrous-extrapure-8006-54-0, Diakses 19 Oktober 2021.

Sulaswatty, A., Rusli, M. S., Abimanyu, H., & Tursiloadi, S. 2019. Minyak Serai Wangi dan Produk Turunannya. In Lembaga Ilmu Pengetahuan Indonesia (LIPI), 9(2).

Tse, J. L. M., Flin, R., & Mearns, K. 2007. Facets of Job Effort in Bus Driver Health: Deconstructing “Effort” in the Effort-Reward Imbalance Model. Journal of Occupational Health Psychology, 12(1): 48–62. https://doi.org/10.1037/1076-8998.12.1.48

Tucker, J. S., Sinclair, R. R., Mohr, C. D., Adler, A. B., Thomas, J. L., & Salvi, A. D. 2008. A Temporal Investigation of the Direct, Interactive, and Reverse Relations Between Demand and Control and Affective Strain. Work and Stress, 22(2): 81–95. https://doi.org/10.1080/02678370802190383

Warnida, H., Putri, D. S., & Sukawaty, Y. 2016. Formula Lipstik dengan Pewarna Alami dari Ekstrak Kelopak Bunga Rosella (Hibiscus sabdariffa L.). Jurnal Ilmu Farmasi Terapan dan Kesehatan, 1(1): 8–14.

Yanhendri, S. W. Y. 2012. Berbagai Bentuk Sediaan Topikal dalam Dermatogical. Cermin Dunia Kedokteran-194, 39(6): 423–430.

Zaituni, Z., Khathir, R., & Agustina, R. 2016. Penyulingan Minyak Atsiri Sereh Dapur (Cymbopogon citratus) dengan Metode Penyulingan Air-Uap. Jurnal Ilmiah Mahasiswa Pertanian, 1(1): 1009–1016. https://doi.org/10.17969/jimfp.v1i1.1085

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Published

31-12-2021

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