Pengaruh HPMC Gel Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Sifat Fisik dan Aktivitas Antibakter

Authors

  • Ferdy Firmansyah jurnal editor Sekolah Tinggi Ilmu Farmasi Riau

Keywords:

Averrhoa bilimbi L, antibacterial, gel, HPMC

Abstract

Bilimbi fruit (Averrhoa bilimbi L) has a antibacterial activity. Ethanol extract of bilimbi fruit is a potentially clear up acne which is caused by
bacterium Propionibacterium acnes. This research is conducted to determine the effect of HPMC of bilimbi fruit ethanol extract gel on physical
nature and the activity of P. acnes. Bilimbi fruit liquid extract is obtained using maceration method with ethanol 80%. It is evaporated, the liquid
extract becomes condensed. This research use three variants each contains 5,0%; 7,0%; and 9,0% of basic of HPMC. The test of organoleptic,
homogenity, pH, and gel physical nature that embody adhesion test, scatter test, viscosity test are conducted on the gel. Antibacterial activity test was
conducted using diffusion method (secara sumuran). The antibacterial activity was measured by the size of its diameter of inhibitory zone which was
form in the media. The result data of physical nature of gel is analyzed by linear correlation of regression. Meanwhile, the result data of antibacterial
activity test was analyzed by statistical test using the method of ANOVA. The result of this research shows that when the level of HPMC is
increasing, its adhesion and its viscosity is getting tighter. Analytical result statistically shows that the antibacterial activity of the gel has the same
inhibitory zone with extract and peroxide benzoyl.

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Published

01-03-2018

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Articles